Syphilis is a really common STD. Syphilis is spread through vaginal, anal, and oral sex. Syphilis is easily cured with antibiotic medicine, but it can cause permanent damage if you don’t get treated. Syphilis is spread from sexual skin-to-skin contact with someone who has it. You get it when your vulva, vagina, penis, anus, or mouth touches someone’s syphilis sores — usually during sex.